What 5-Amino-1MQ is
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule research compound, not a peptide. It is included in this profile series because it is commonly supplied alongside research peptides. It has been characterised as an inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), which methylates nicotinamide and depletes methyl donors.
Molecular information
- Compound class: Small-molecule NNMT inhibitor (quinolinium derivative)
- Approximate molecular mass: ~159 g/mol (as the free base; salt forms differ)
- Physical form: Typically supplied as a powder
Areas of published research
Preclinical published research has examined the effect of NNMT inhibition on adipose-tissue metabolism, cellular NAD+ pools and metabolic-syndrome models. Because 5-Amino-1MQ is a small molecule rather than a peptide, analytical considerations are chemistry-specific (LC-MS with electrospray or APCI, UV/Vis characterisation) and differ from peptide-specific HPLC/LC-MS workflows.
Analytical considerations
Standard research-peptide analytical checks apply: identity confirmation by mass spectrometry (see LC-MS peptide testing explained), purity assessment by reversed-phase HPLC at 214 nm (see what is HPLC peptide testing), and batch-specific documentation (see how to read a peptide COA). Refer to the Peptovia Research Certificate of Analysis page for live examples of the analytical format used for batches supplied.
Further reading
Peer-reviewed literature on 5-Amino-1MQ is accessible via PubMed and specialist journals. Readers are encouraged to evaluate primary sources directly rather than relying on secondary summaries.
Research Use Only. This profile is an educational overview of 5-Amino-1MQ as a research peptide. It does not describe or recommend human, veterinary or clinical use. Peptovia Research supplies 5-Amino-1MQ strictly for in-vitro laboratory research. No dosing, administration or therapeutic guidance is provided or implied.