What CJC-1295 is
CJC-1295 is a synthetic analogue of the growth hormone-releasing factor GRF(1-29), with four amino-acid substitutions to improve chemical stability. Two research forms exist: CJC-1295 with DAC, incorporating a maleimidopropionyl-Lys linker that binds to plasma albumin and substantially extends half-life; and CJC-1295 without DAC (also called modified GRF 1-29), lacking the albumin-binding linker and cleared more rapidly. CJC-1295 is often supplied and studied alongside Ipamorelin.
Molecular information
- Sequence origin: GRF(1-29) with substitutions at positions 2, 8, 15 and 27
- Number of residues in the peptide chain: 30 (with DAC linker) / 29 (without DAC)
- Approximate mass: ~3.65 kDa (with DAC) / ~3.36 kDa (without DAC)
- Physical form: Typically supplied as a white lyophilised powder
Areas of published research
Published preclinical research has examined the effect of stabilised GRF analogues on growth-hormone pulsatility and downstream IGF-1 responses. The DAC-linked variant's albumin binding is central to its extended half-life and is well characterised in the literature. Analytical work requires reversed-phase HPLC with a gradient sufficient to resolve deletion sequences, and LC-MS to confirm identity — particularly the presence of the DAC linker in the DAC-containing form.
Analytical considerations
Standard research-peptide analytical checks apply: identity confirmation by mass spectrometry (see LC-MS peptide testing explained), purity assessment by reversed-phase HPLC at 214 nm (see what is HPLC peptide testing), and batch-specific documentation (see how to read a peptide COA). Refer to the Peptovia Research Certificate of Analysis page for live examples of the analytical format used for batches supplied.
Further reading
Peer-reviewed literature on CJC-1295 is accessible via PubMed and specialist journals. Readers are encouraged to evaluate primary sources directly rather than relying on secondary summaries.
Research Use Only. This profile is an educational overview of CJC-1295 as a research peptide. It does not describe or recommend human, veterinary or clinical use. Peptovia Research supplies CJC-1295 strictly for in-vitro laboratory research. No dosing, administration or therapeutic guidance is provided or implied.