What GHRP-6 is
GHRP-6 is a synthetic hexapeptide developed in the 1980s as a research probe for the growth-hormone secretagogue receptor, before the discovery of the natural ligand ghrelin. It remains one of the most-cited ghrelin-receptor agonists in the literature.
Molecular information
- Sequence: His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂
- Number of residues: 6
- Approximate monoisotopic mass: ~872 Da (as the free acid)
- Physical form: Typically supplied as a white lyophilised powder
Areas of published research
GHRP-6 has been used extensively as a research tool for probing ghrelin-receptor signalling and growth-hormone release mechanisms. Its role in identifying and characterising the ghrelin receptor is a foundational chapter in the field. Non-natural D-amino acids in the sequence require careful handling of mass-spectrometry data.
Analytical considerations
Standard research-peptide analytical checks apply: identity confirmation by mass spectrometry (see LC-MS peptide testing explained), purity assessment by reversed-phase HPLC at 214 nm (see what is HPLC peptide testing), and batch-specific documentation (see how to read a peptide COA). Refer to the Peptovia Research Certificate of Analysis page for live examples of the analytical format used for batches supplied.
Further reading
Peer-reviewed literature on GHRP-6 is accessible via PubMed and specialist journals. Readers are encouraged to evaluate primary sources directly rather than relying on secondary summaries.
Research Use Only. This profile is an educational overview of GHRP-6 as a research peptide. It does not describe or recommend human, veterinary or clinical use. Peptovia Research supplies GHRP-6 strictly for in-vitro laboratory research. No dosing, administration or therapeutic guidance is provided or implied.