What KPV is
KPV is a naturally occurring tripeptide corresponding to the C-terminal three residues of α-melanocyte-stimulating hormone (α-MSH). Its short sequence and small size have made it a convenient research tool for probing the anti-inflammatory activity that has been attributed to the C-terminus of α-MSH.
Molecular information
- Sequence: Lys-Pro-Val (KPV)
- Number of residues: 3
- Approximate monoisotopic mass: ~342 Da (as the free acid)
- Physical form: Typically supplied as a white lyophilised powder
Areas of published research
Preclinical research on KPV has examined its influence on inflammatory signalling in cell culture and in animal models of mucosal inflammation. As a very short peptide, KPV can be chromatographically challenging to retain on standard reversed-phase columns; ion-pairing agents or specialist method conditions may be required.
Analytical considerations
Standard research-peptide analytical checks apply: identity confirmation by mass spectrometry (see LC-MS peptide testing explained), purity assessment by reversed-phase HPLC at 214 nm (see what is HPLC peptide testing), and batch-specific documentation (see how to read a peptide COA). Refer to the Peptovia Research Certificate of Analysis page for live examples of the analytical format used for batches supplied.
Further reading
Peer-reviewed literature on KPV is accessible via PubMed and specialist journals. Readers are encouraged to evaluate primary sources directly rather than relying on secondary summaries.
Research Use Only. This profile is an educational overview of KPV as a research peptide. It does not describe or recommend human, veterinary or clinical use. Peptovia Research supplies KPV strictly for in-vitro laboratory research. No dosing, administration or therapeutic guidance is provided or implied.