What Melanotan-2 (MT-2) is
Melanotan-2 (also called MT-2) is a synthetic cyclic heptapeptide analogue of α-melanocyte-stimulating hormone (α-MSH), developed as a research probe for melanocortin-receptor signalling.
Molecular information
- Sequence: Cyclic [Nle-Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
- Number of residues: 7 (cyclic, via a lactam bridge between the Asp side chain and Lys side chain)
- Approximate monoisotopic mass: ~1024 Da (as the free acid)
- Physical form: Typically supplied as a white lyophilised powder
Areas of published research
Preclinical research on Melanotan-2 has examined its activity at melanocortin receptors (MC1R, MC3R, MC4R, MC5R). The cyclic structure and non-natural residues (Nle, D-Phe) are analytically significant: identity confirmation should verify the cyclic-bridge closure by mass, since a linear synthesis by-product will differ in mass and behave differently on HPLC.
Analytical considerations
Standard research-peptide analytical checks apply: identity confirmation by mass spectrometry (see LC-MS peptide testing explained), purity assessment by reversed-phase HPLC at 214 nm (see what is HPLC peptide testing), and batch-specific documentation (see how to read a peptide COA). Refer to the Peptovia Research Certificate of Analysis page for live examples of the analytical format used for batches supplied.
Further reading
Peer-reviewed literature on Melanotan-2 (MT-2) is accessible via PubMed and specialist journals. Readers are encouraged to evaluate primary sources directly rather than relying on secondary summaries.
Research Use Only. This profile is an educational overview of Melanotan-2 (MT-2) as a research peptide. It does not describe or recommend human, veterinary or clinical use. Peptovia Research supplies Melanotan-2 (MT-2) strictly for in-vitro laboratory research. No dosing, administration or therapeutic guidance is provided or implied.